Café Scientifique – Dr Melissa Fullwood

Date: 10th February 2012

Time: 4:30pm to 5:30pm

Venue: OpenLab (Blk E Lvl 1M)

Dr Melissa J. Fullwood, Lee Kuan Yew Post-Doctoral Fellow, A*STAR-Duke-NUS Neuroscience Research Partnership

Abstract: The finishing of the human genome sequence showed that raw genomic sequences would not be medically useful. Annotation of the genome sequence is necessary to make personal genome sequencing relevant to human health. A better understanding of human genetics and epigenetics will help us better understand diseases, such as cancer, which occurs due to genetic or epigenetic mutations. Recently, tremendous advances in DNA sequencing throughput, speed, and cost have beenmade in so-called “next-generation” sequencing, allowing powerful ultra-high-throughput, genome-wide annotation of genomic elements for functional characterization of the human genome, which have revealed many interesting features of the human genome, for example, the growing realization that that non-coding regions contain a plethora of functional genomic elements. In these conversations, I hope to discuss genomics, particularly as applied to human health, but please also feel free to ask me anything at all!


Dr. Melissa J. Fullwood completed her undergraduate degree in Biological Sciences in 2005 at Stanford University, with honors, distinction and Phi Beta Kappa. She completed her PhD with the National University of Singapore Graduate School for Integrative Sciences and Engineering (NGS) in 2009, at the Genome Technology and Biology lab of the Genome Institute of Singapore with Dr Ruan Yijun as her PhD supervisor. For her PhD, together with Dr Ruan Yijun, Dr Chia-Lin Wei, Dr Edwin Cheung and Professor Edison Liu, she developed a method called ChIA-PET for investigations into chromatin interactions using massively parallel Paired End Tag sequencing, and found that chromatin interactions between oestrogen receptor alpha binding sites are common in breast cancer cells. This work received funding from the National Institutes of Health in the United States under the “ENCODE” consortium, and was published in Nature.

Please sign up at (only space for 15 students)

What is Café Scientifique?

The concept of Café Scientific is to create an informal and causual setting to discuss thought-provoking scientific issues. Everyone is welcome.

The Raffles Science Institute will organise more of such sessions on Friday afternoons at the OpenLab.


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